拷貝漫畫

张灏

病理学与病理生理学 教授

#,#,#,,,,,,,,,,,,,,*.Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma. Clin Cancer Res.2019;25(10):3035-3045.

18.Xiong X#, Liu J#, Wu X#, Yao Z, Meng Y, Liu S, Chen Y, Ren H, Gao S, Qiu X*,Zhang H*.PTPRO represses breast cancer lung metastasis by inhibiting the JAK2-YAP axis.Scientific reports. J Control Release. 2025 Feb 10:378:438-459.

19.Du L#,Wang L#,Gan J#,Yao Z,Lin W,Li J,Guo Y,Chen Y,Zhou F*,Jim Yeung SC,Coppes RP,Zhang D,Zhang H*.MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience.2019;22:353-368..

20.Gan J#,Ke X#,Jiang J#,Dong H#, Yao Z,Lin Y,Lin W,Wu X,Yan S, Zhuang Y,Chu WK,Cai R,Zhang X,Cheung HS,Block NL,Pang CP,Schally AV, Zhang H*.Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signaling. Proc Natl Acad Sci U S A.2016;113(51):14745-14750. 

21.Dong H#,Ma L#,Gan J,Lin W,Chen C,Yao Z,Du L,Zheng L,Ke C,Huang X,Song H,Kumar R,Yeung SC*,Zhang H*.PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2. Oncogene.2017;36(3):410-422.

22.Dong H,Xu J,Li W,Gan J,Lin W,Ke J,Jiang J,Du L,Chen Y,Zhong X, Zhang D,Yeung SC,Li X,Zhang H*.Reciprocal androgen receptor/interleukin-6 crosstalk drives oesophageal carcinoma progression and contributes to patient prognosis. J Pathol.2017;241(4):448-462.

23.Xu B,Jiang X,Xiong J,Lan J,Tian Y,Zhong L,Wang X,Xu N,Cao H, Zhang W,Zhang H,Hong X,Zhan YY*,Zhang Y*, Hu T*.Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020;63(11):5841-5855. 

24.Bhagelu R.Achyut, Zhang H*,Kartik Angara,Nahid F.Mivechi,Ali S. Arbab, Lan Ko*.Oncoprotein GT198 Vaccination Delays Tumor Growth in MMTV-PyMT Mice.  Cancer Lett. 2020;476:57-66.  

25.Achyut BR, Zhang H, Angara K, Mivechi NF, Arbab AS, Ko L. Achyut BR, Zhang H, Angara K, Mivechi NF, Arbab AS, Ko L. Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice. Cancer Lett. 2020;476:57-66. 

26.Yao Z#,Du L#,Xu M, Li K,Guo H,Ye G,Zhang D,Coppes RP,Zhang H*. MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma. Front Oncol.2019;9:816.

27. Ke X,Xiong X,Lin Y,Zhang H*.Chimeric RNA and Exosomes-Based Liquid Biopsy.  Methods Mol Biol.2020;2079:211-218.

28.Tamiya H#,Kim H#,Klymenko O,Kim H*,Feng Y,Zhang T,Han JY, Murao A,Snipas SJ,Jilaveanu L,Brown K,Kluger H,Zhang H,Iwai K,Ronai ZA*.SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. J Clin Invest.2018;128(1):517-530. 

29.Wang W#,Lim KG#,Feng M,Bao Y,Lee PL,Cai Y,Chen Y,Zhang H, Marzese D,Hoon DSB,Yu Q*.KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer .Mol Cancer Ther.2018;17(9):1973-1983.

30.Wang L,Li K,Lin X,Yao Z,Wang S,Xiong X,Ning Z,Wang J,Xu X,Jiang Y,Liu D,Chen Y,Zhang D,Zhang H*.Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis. Cancer Lett.2019;450:22-31.

31.Feng Y#,Ke C#,Tang Q#,Dong H,Zheng X,Lin W,Ke J,Huang J,Yeung SC,Zhang H*.Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell Death Dis.2014;5(2):e1088.

32.Li Z#,Zou X#,Xie L,Chen H,Chen Y,Yeung SC,Zhang H*.Personalizing risk stratification by addition of PAK1 expression to TNM staging: improving the accuracy of clinical decision for gastroesophageal junction adenocarcinoma.Int J Cancer.2015;136(7):1636-45. 

33.Zhang H*,Lin W,Kannan K,uo L,Li J,Chao PW,Wang Y,Chen YP,Gu J,Yen L*.Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma.Oncotarget.2013;4(11):2135-43.

34.Yu J#,Lin Y#,Xiong X#,Li K,Yao Z,Dong H,Jiang Z,Yu D,Yeung SJ,Zhang H*.Detection of Exosomal PD-L1 RNA in Saliva of Patients With Periodontitis. Front Genet.2019;10:202. 

35.Wang L,Li W,Li K,Guo Y,Liu D,Yao Z,Lin X,Li S,Jiang Z,Liu Q,Jiang Y, Zhang B,Chen L,Zhou F,Ren H,Lin D,Zhang D,Yeung SJ,Zhang H*.The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma. Cancer Med. 2018;7(10):5205-5216.

36.Tang Q,Li G,Wei X,Zhang J,Chiu JF,Hasenmayer D,Zhang D,Zhang H*. Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett. 2013;336(2):325-37.

37.You Y,Chen Y,Zheng X,Meltzer SJ,Zhang H*.Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients.Cancer Lett. 2012;315(2):138-44.

38.Zhang H,Singh RR,Talukder AH,Kumar R*.Metastatic tumor antigen is a direct corepressor of the Wnt4 pathway.Genes Dev.2006;20(21):2943-8.

39.Zhang H,Kuang SQ,Liao L,Zhou S,Xu J*.Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary tumorigenesis in mice.Cancer Res.2004;64(19):7169-77.

40.Zhang H,Stephens LC,Kumar R*.Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Clin Cancer Res. 2006;12(5):1479-86.

41.Zhou C*,Wu Y,Chen G,Liu X,Zhu Y,Lu S,Feng J,He J,Han B,Wang J, Jiang G, Hu C,Zhang H,Cheng G,Song X,Lu Y,Pan H,Zheng W,Yin AY. BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study of First-Line Carboplatin/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non-Small-Cell Lung Cancer.J Clin Oncol.2015;33(19):2197-204.

42.Kumar R*,Zhang H,Holm C,Vadlamudi RK,Landberg G,Rayala SK*. Extranuclear coactivator signaling confers insensitivity to tamoxifen.Clin Cancer Res.2009;15(12):4123-30.

43.Peng M,Zhang H,Jaafar L,Risinger JI,Huang S,Mivechi NF,Ko L*. Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations.J Biol Chem. 2013;288(46):33387-97.

44.Tong Z#,Li M#,Wang W,Mo P,Yu L,Liu K,Ren W,Li W,Zhang H,Xu J, Yu C*.Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/beta-Catenin Signaling.J Biol Chem.2015;290(30):18596-608.

45.Chu WK,Law KS,Chan SO,Yam JC,Chen LJ,Zhang H,Cheung HS, Block NL,Schally AV*,Pang CP*.Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells.Proc Natl Acad Sci USA.2016;113(50):14396-14401.

46.Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy.2016;12(1): 1-222.

47.Chen T,Chen Q,Xu Y,Zhou Q,Zhu J,Zhang H,Wu Q,Xu J,Yu C*.SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.JHepatol.2012;56(1):210-7. 

48.Zhang S,Zeng D,Peng Y,Yang Y,Zhuang X,Li Z,Wang M,Chen L,Zhang H*.Cancer-related fatigue and chemotherapy-associated adverse effects:correlation with TNF-α, IL-1 and 17-hydroxycorticosteroids.Future Oncol.2014;10(9):1619-26.


学术著作


1.《Encyclopedia of Cancer 》(癌症百科全书)《Springer出版社》编委;

2.《肿瘤急症治疗例析》《人民卫生出版社》主编,2023年;

3.《Chimeric RNA: Methods and Protocols》《Springer出版社》编委;2020年;

4.《乳腺癌》《人民卫生出版社》副主编,2011年;

5.《细胞外囊泡》《科学出版社》编委,2019年;

6.《肿瘤标志物》《人民卫生出版社》编委,2022年;

7.《肿瘤标志物通讯》(外泌体专刊)《中国抗癌协会出版》主编,2018年;

8.《Extracellular Vesicles: From Bench to Bedside》编委.2024年


获奖及荣誉 


1. 牙龈卟啉单胞菌诱发微生态失衡促进食管癌发生发展的机制及应用,河南省科学技术进步奖,一等奖,2023年 

2. 食管癌肿瘤标志物及液体活检的应用与开发,广东省科技厅,广东省科学技术科技进步奖,二等奖,2020年

3. 牙龈卟啉单胞菌促进食管癌发生发展病因的阐明及应用,中华医学会,中华医学科学技术奖三等奖,2023年 

4. 广东省医学会科技进步奖励二等奖《液体活检和老药新用诊治食管癌新机制,新靶点和转化研究》 2024年

5. 食管癌早期诊断和治疗新方法的转化研究,广东省医学会,广东省医学会科技进步奖,二等奖,2019年

6. 低剂量二甲双胍重编程食管癌免疫微环境:II期临床研究,Gastroenterology Report,《中华胃肠外科杂志》《中华炎性肠病杂志》联合颁发, 2020年度十佳消化道领域临床研究金奖,2020年

7. 中国产学研合作创新与促进奖,中国产学研合作促进会,2021年

8. 上消化道肿瘤诊断和治疗新方法的转化研究,汕头市科学技术奖励,一等奖,2018年

9. 食管癌化疗敏感性标志物和诊疗新方法的研究及应用,广东省药学会医院药学科学技术奖,一等奖,2020年

10. 食管癌化疗敏感性标志物和诊疗新方法的研究及应用,中国药学会科学技术奖,三等奖,2020年

11. 药物基因组学和纳米载体在肿瘤药物治疗中的应用及评价,2019年度广东省优秀科技成果

12.《金博奖全球高层人才科技创新大赛金奖》,2021年

13.《中国研究型医院学会医学研究创新奖一等奖》2022年

14.《Wiley中国开放科学高贡献奖》2022年

15.《2022中国生物医药企业最具创新力50强奖》2022年


指导团队青年成员研究生本科生获得过如下项目:

1. 2020年第三届粤港澳大湾区医学与健康发展论坛获得一等奖

2. 2020年拷貝漫畫 生命科学创新奖获得二等奖

3. 2021年第四届粤港澳大湾区医学与健康发展论坛获得二等奖

4. 2021年拷貝漫畫 生命科学创新奖获得二等奖

5. 2021年中国抗癌协会肿瘤标志物外泌体专委会细胞外囊泡与循环核酸期刊组织外泌体和微囊泡论坛奖。

6. 2021年金博奖全球高层次人才科技创新大赛获得创新组金奖

7. 2023年拷貝漫畫 第四届“全国大学生基础医学创新研究暨实验设计论坛”中荣获临床医学赛道实验设计组三等奖

8. 2024年拷貝漫畫 第五届基础医学创新研究暨实验设计竞赛三等奖

9. 2024年荣获第二届广东省高校实验室安全知识校际邀请赛微视频校内选拔赛二等奖

10. 2024年拷貝漫畫 第十二届“挑战杯”大学生创业计划竞赛“获得银奖

11. 2025年拷貝漫畫 第六届医学创新大赛暨“一带一路”国际竞赛三等奖。


学术兼职


1.中国抗癌协会肿瘤标志专业委员会外泌体技术专家委员会(CSEMV)主委

2.《外泌体研究转化和临床应用专家共识》专家组组长

3.Cancer Letters(Elsevier 出版社)和Scientific Report(Nature出版社)编委

4.(Extracellular Vesicles & Circulating Nucleic Acids)和(Extracellular Vesicle)编委

5.Annals of Medicine(Taylor & Francis 出版社)肿瘤学主编

6.Cancer Research,Clinical Cancer Research,Oncogene & PNAS等杂志的审稿专家

7.《胰腺癌诊治指南》撰写组专家

8.中国抗癌协会肿瘤标志专业委员会常务委员

9.中国抗癌协会肿瘤标志物专业委员会常委

10.中国抗癌协会肿瘤代谢委员会常委

11.中国临床肿瘤协会胰腺癌专家委员会常委

12.亚太医学生物免疫学会肿瘤学分会副主委

13.广东省抗癌协会肿瘤代谢委员会副主委

14.广东省抗癌协会肿瘤标志物专业委员会副主委

15.广东省抗癌协会抗肿瘤药物专业委员会副主委